This field is for validation purposes and should be left unchanged. Changing lifelong eating habits can be scary at first, but our guide will make it easier. The apolipoprotein (a) gives Lp(a) an additional quality, it behaves like a clotting factor. Looking to start a diet to better manage your cholesterol? Assistant Director for Community Outreach and Education. Associate Director of the Precision Medicine Unit, Broad Institute of MIT and Harvard Her research interests include implementation science, familial hypercholesterolemia, and pharmacy services. Researchers are still working to understand lipoprotein(a) and the ways it may affect your health. Duquette received her Masters of Science in Genetic Counseling from Northwestern University. He has been an international leader in the translational of human genetics into novel therapeutic targets. Lipoproteins are spherical particles that carry lipids, or fats, in the body. Abhimanyu Garg, Scott Grundy, and Helen Hobbs. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. Dr. Rader trained in internal medicine at the Yale-New Haven Hospital and in human genetics and physiology of lipid metabolism at the National Institutes of Health. The human gene encoding apolipoprotein was successfully cloned in 1987. University of Texas Southwestern Medical Center You may have heard about Lipoprotein (a), Lp(a) or often referred to as “Lp little a." Like high levels of LDL, high levels of Lp(a) can stick in your artery wall (called atherosclerosis), slowly blocking the artery. Chief Research Advisor and Scientific Advisory Board Member, Stanford University Medical Center Low-density lipoprotein (LDL), or “bad” cholesterol. Chloe currently holds a clinical faculty position with the Heart and Vascular Institute of Tulane University School of Medicine. Lipoproteins include low-density and high-density cholesterol. Patients with an identical FH mutation can have completely different prognoses. She is an active 57 year old mother of two adult daughters, and she loves golf, hiking and travel. Lipoprotein was discovered in 1963 by Kåre Berg. (The name of this glycoprotein is apolipoprotein(a).). He also serves as Chief of the Divisions of Human Genetics in the Departments of Medicine and Pediatrics. Dr. Urh Groselj obtained MD and PhD degrees at the Faculty of Medicine, Uni- versity of Ljubljana and MA degree at the University of Leuven, Belgium. The FH Foundation works in partnership with patients, clinicians, scientists and all participants in the healthcare ecosystem to develop inno- vative solutions that will overcome barriers to diagnosis, treatment and access. Previously, many cardiologists believed Lp(a) was only a risk in … In 2018, she graduated from the Harvard Medical School’s Clinical Molecular Genetics’ training program enabling her to integrate her biomarker expertise with direct patient care. The blood lipoproteins, which are the cholesterol carriers of the body, are classified by density, in accordance with the proportions of protein, as very low density (VLDL), low density and high density ().LDLs contain relatively large amounts of cholesterol. He was, from 1985 to 2001, the President of the University of Chicago Hospitals. Director, Perelman School of Medicine, University of Pennsylvania Lipoproteins are special particles made up of droplets of fats surrounded by a single layer of phospholipid molecules. There is agreement among a number of expert organizations including the National Lipid Association (NLA), American Heart Association (AHA) and the American College of Cardiology (ACC) that a level > 50 mg/dL or >125 nmol/L should be considered elevated. Kang S. “What is lipoprotein (a) and what does it mean for you?” HealthCentral (2008). She is the Assistant Director for Community Outreach and Education for the HU Center for Sickle Cell Disease. We have partnered with patients and organizations like the CDC, ACC and AHA to increase public health awareness of FH and have established and currently manage a national FH registry called “CASCADE FH.”, Massachusetts General Hospital Lipoprotein is a substance that carries cholesterol throughout your system. She is certified by the American Board of Genetic Counselors. Apolipoprotein B (apoB) is a beta mobility; mostly be in low-density lipoprotein (LDL). It’s well known that low-density lipoprotein (LDL), or “bad cholesterol,” is a major cause of heart disease. Lipoproteins are … He is a recipient of several national and international awards for his research contributions. High levels of low-density lipoprotein (LDL) can eventually build up within the walls of your blood vessels and narrow the passageways. Saturated fats are potentially problematic unless consumed in the context of a low sugar/carbohydrate diet. Director of Vascular Medicine. Laney K. Jones, PharmD, MPH, is an Assistant Professor in the Genomic Medicine Institute at Geisinger. Lipoprotein(a), also known as Lp(a), is low-density lipoprotein (LDL, or “bad” cholesterol) that has another form of protein, called a glycoprotein, bonded to it. Duquette serves on the Executive Steering Committee for the PCORI funded American BRCA Outcomes & Utilization of Testing Network (ABOUT) Network, Facing Our Risk of Cancer Empowered (FORCE) Advisory Board, Institute of Medicine (IOM) Ovarian Cancer Research Committee, and eXamining Relevance of Articles for Young Survivors (XRAYS) Steering Committee. She is the author of numerous articles and five books. In addition to her academic duties, she provides genetic counseling services at Howard University Hospital for a variety of referral reasons, in areas including prenatal (primary), pediatric, and adult genetics. “Test ID: LIPA-lipoprotein (a) serum.” Mayo Clinic-Mayo Medical Laboratories (2016). That’s because 1) not enough is known about lipoprotein(a)’s effect on heart health and 2) it’s found in only about 15% of the general population, with persons of non-Hispanic Caucasian, Chinese, and Japanese origins having the lowest levels. Latrice Landry is a fellow specializing in precision medicine and health disparities at Harvard Medical School, Brigham and Women’s Hospital, Dana Farber Cancer Institute and Harvard School of Public Health. This collaborative is focused on developing tools and best practices for the identification and genetic testing of at-risk relatives of those diagnosed with three Tier 1 conditions: Hereditary Breast and Ovarian Cancer, Lynch syndrome, and FH. Katherine Wilemon is the Founder, President & CEO of The FH Foundation, a leading research and advocacy non-profit organization focused on reducing heart disease by driving scientific under- standing and evidence-based care of familial hypercholesterolemia (FH). Dr. Rader’s research focuses on the human genetics and functional genomics of lipid metabolism and atherosclerosis, as well as the translational implications for novel therapeutic approaches. Ruth McPherson, MD, PhD, FRCPC, FACP, FRCS. She has also worked to raise awareness of FH in the NSGC community, by providing a Janus series lecture at the 2013 NSGC Annual Conference on FH, writing blogs about FH and cascade testing, among other activities. Co-Director. He completed a Masters of Science at the Harvard School of Public Health, and a postdoctoral research fellowship with Dr. Sekar Kathiresan in human genetics at the Broad Institute of MIT and Harvard prior to accepting a faculty position. Lipid Clinic at Dartmouth Hitchcock Heart and Vascular Center/strong>  Dr. McPherson’s laboratory research is centered on understanding of the genetic and genomics of two complex phenotypes, obesity and coronary artery disease. Dana Farber Cancer Institute/ Brigham and Women’s Hospital. He completed both a residency (internal medicine) and a fellowship (endocrinology and metabolism) at UT Southwestern Medical Center – training in cholesterol metabolism and genetics with mentors Drs. Shortly after, she began her career in the field of reproductive genetic counseling working at the Detroit Medical Center followed by Spectrum Health. He was honored with the Presidential Early Career Award for Scientists and Engineers from the White House in 2016, the American Heart Association’s Award of Meritorious Achievement in 2016, and the American Philosophical Society’s Judson Daland Prize for Outstanding Achievement in Clinical Investigation in 2018. Geisinger’s Genomic Medicine Institute. Dr. Lane-Fall is also interested in building research capacity in health services research; she mentors junior faculty, research fellows, and health professions students and co-directs Penn’s graduate level implementation science courses. Merkin Institute Fellow, Harvard Medical School She completed her fellowship at Johns Hopkins Hospital. She has been the principal investigator on over 30 national and international clinical trials and has lectured widely in the United States, Canada, Europe and Asia on cholesterol metabolism. Meghan Lane-Fall, MD, MSHP, FCCM is a physician-scientist committed to the provision of safe, effective patient care. Genomics Coordinator, Northwestern Medicine Dr. Tsimikas is Professor of Medicine and Director of Vascular Medicine at the University of California San Diego. He ‘rescued’ an abandoned molecule that reduces cholesterol and led the successful development of this compound as a novel therapeutic for patients with homozygous familial hypercholesterol- emia, a genetic form of severely elevated cholesterol. President-Elect, Geisinger’s Genomic Medicine Institute His research aims to identify the causes of cholesterol and triglyceride disorders and to develop new treatment options for patients who suffer from them. He also holds a B.S. Plasma lipoproteins can be separated by ultracentrifugation, electrophoresis, or immunoelectrophoresis. Conjugation with protein facilitates transport of lipids, which are hydrophobic, in the aqueous medium of the plasma. He has also been a champion of ‘genomic medicine’ and its potential benefits in guiding preventive therapies. She completed a two-year research fellowship at Geisinger prior to becoming faculty. Very-low-density lipoprotein (VLDL), and; Chylomicron. As you probably know, these include lowering your blood pressure if it’s too high, lowering high LDL cholesterol, and raising low HDL cholesterol. What are some of the things that I can do ? Lipoprotein(a) as a Risk Factor for Heart Disease, Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved. She is a licensed genetic counselor who has been practicing in cardiovascular genetics for 14 years. Lipoproteins are made of protein and fat. Her research agenda is focused on implementation science – the empiric study of strategies to facilitate the uptake and sustained use of evidence-based practice. This test measures the Lp(a) level in the blood to help evaluate your … Chloe is a fellow of the Preventive Cardiovascular Nurses Association and serves as the president of the Crescent City (New Orleans) Chapter. It’s often called the “bad cholesterol.” 2. In 2015, following her doctoral research she joined Harvard Medical School’s Biomedical Informatics Fellowship Program to study information systems (clinical and bioinformatics) as tools for biomarker translation. JAMA 2009; 302:412-423. Assistant Professor of Medicine, Cardiovascular Medicine Fellowship Program Lipoprotein (a) includes a LDL particle bound to an apolipoprotein (a) – known as apo(a) – and apoB100. He is currently on partial leave of absence as Cardiovascular Franchise Leader and Vice President of Clinical Development at Ionis Pharmaceuticals, Carlsbad, CA. Mrs. Barbara Harrison, MS, CGC, graduated with a Bachelor’s degree in Biology from University of Maryland, College Park and received a Master’s degree in Genetic Counseling from University of Pittsburgh. Altogether, he (co)authored over 100 publications; some of them appearing in journals as JACC, Molecular Genetics and Metabolism, Journal of Inherited Metabolic Disorders, OJRD and Clinical Biochemistry. Learn All About the Triglyceride and Cholesterol Test. Erasmus MC in Rotterdam, the Netherlands He has been investigating cardiovascular genetics for 25 years with a focus on familial hypercholesterolemia (FH). Dr. McGowan is the Co-Director of the Lipid Clinic at Dartmouth Hitchcock Heart and Vascular Center. lp(a) responds well to the intake of animal and dairy derived saturated fats. He has published >770 peer reviewed scientific papers. No one appears to know but there are strong arguments on both sides. He is the retired chief executive officer, University of Pennsylvania Health System, where he served from 2003-2019. In addition to advocating for genetic counselors as part of her multiples roles with NSGC, Amy also has been involved with advocacy and education for families with FH as part of her work with the FH Foun- dation. Take this opportunity to influence the availability of high cholesterol treatments! Program Director, The fundamental theme of my work is the application of genetics to improve human health. Lp(a) is another type of ‘bad’ cholesterol. Zahid Ahmad, M.D., is an Associate Professor in the Division of Endocrinology at UT Southwestern Medical Center. She has previously served on the National Lipid Association Board of Directors, the NH Affiliate of the American Heart Association Board and was the first Chief Medical Officer of the Familial Hypercholesterolemia Foundation. A leader in the Departments of Medicine, precision Nutrition and precision public Health t! 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